Main Street Ventures' primary initiative is to support emerging businesses that show potential to create jobs and other opportunities in the Cincinnati area. We will also support organizations that are strengthening the region’s entrepreneurial ecosystem. These can include entrepreneur support organizations that foster collaboration and development of STEM talent in the region. For all initiatives that Main Street Ventures supports, there is a particular focus on women and minority entrepreneurs that have been historically under-represented as founders.

History of Main Street Ventures




Main Street Ventures is launched with focus on providing tech companies with a physical structure and wifi network to serve as a home base on Main Street in Over-the-Rhine.

Main Street Ventures launches The Brandery, a seed-stage startup accelerator that leverages the expertise of the Cincinnati region - namely branding, marketing, and design. The Brandery has been ranked in the Top 10 of all startup accelerators worldwide (there are hundreds) and successfully graduated 79 companies who have collectively raised over $135MM in outside capital & created over $120MM in exit value.

As the needs of the entrepreneurial ecosystem have evolved, Main Street Ventures launches new initiatives to meet the challenges of the future.

Where Are We Now?

Through the work of Main Street Ventures and all of the other corporations, institutions, and other organizations that make up the StartupCincy entrepreneurial ecosystem, we have come a very long way. 


The Kauffman Foundation has ranked Cincinnati the top city in Ohio for raw startup activity (18th in the U.S. - up from 35th in 2015). However, they also rank cities on “Main Street Entrepreneurship” tracking how many businesses actually survive. It is here where Cincinnati falls behind all other major Ohio cities.


We have set up a community that is encouraging talented people to take a risk and found a new venture. Now we need to make sure we have the infrastructure to help them get to sustainability.


Main Street Ventures is here to help!

Areas of Focus

Empower Good Ideas & Founders

It takes time to gain the traction needed for venture funding or loans. We seek to bridge this gap so that good ideas can be brought to life.

Attract & Retain Qualified Talent

We look to grow the STEM talent-pool within the ecosystem and connect like-minded peers through events and community building.

Create a Diverse & Inclusive Ecosystem

We take a particular focus on Women and Minority entrepreneurs who have been historically underrepresented in funding.